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Molecular authentication of the traditional Chinese medicine Tongren Dahuoluo Wan and its alternative

Jikun WANG, Jing DU, Meng CAO, Lu YAO, Suhua XIE, Jiafu CHEN, Xingbo ZHAO

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 353-357 doi: 10.15302/J-FASE-2017157

Abstract: Tongren Dahuoluo Wan has been a popular traditional Chinese medicine in international pharmaceuticalTherefore, an alternative formulation which substitutes leopard bone with zokor bone in the formula ofFor the patent medicine authentication, we set up a molecular diagnostic assay to resolve the difficultiesof low concentration of target DNAs and presence of PCR-inhibitory substances in this complex medicinerecommend a common technical strategy for authentication of species origins in traditional Chinese medicine

Keywords： Tongren Dahuoluo Wan     molecular diagnostic assay     Eospalax baileyi     Panthera pardus     species-specific primers    

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The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 348-355 doi: 10.1007/s11684-011-0150-x

Abstract: Research into the biological properties and clinical potential of stem cells has spurred strong public investment, industry development, media coverage, and patient interest in recent years. To date, however, few clinical applications of demonstrated safety and efficacy have been developed with the exception of uses of hematopoietic stem cells in the treatment of diseases of the blood and immune systems. This lack of an evidence basis notwithstanding, hundreds of companies and private clinics around the world now sell putative stem cell treatments for an enormously broad range of medical and quality-of-life conditions. This represents a major challenge for legitimate scientists working in the field, for authorities seeking to protect their constituencies, and for patients and consumers targeted by such companies’ marketing strategies. In this review, I provide an overview of the global industry in pseudomedical stem cell treatments, with an investigation of claims in a single disease area (amyotrophic lateral sclerosis), and make recommendations for the introduction and enforcement of appropriate regulatory responses to this problem.

Keywords： stem cell tourism     medical ethics     stem cell policy and regulation     alternative medicine    

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Biofuel as an alternative to oil—current industry progress and sustainable development

Li Shizhong

Strategic Study of CAE 2011, Volume 13, Issue 2,   Pages 50-56

Abstract: For the purpose of a sustainable social-economic development, biofuel is the most viable alternative

Keywords： biofuel     alternative to oil     transport     development    

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Evaluation of the contract reliability for alternative infrastructure project delivery: a contract engineering

Bing WANG, Qingbin CUI, Shuibo ZHANG

Frontiers of Engineering Management 2019, Volume 6, Issue 2,   Pages 239-248 doi: 10.1007/s42524-019-0018-3

Abstract: levels are increasingly motivating the private sector to participate in infrastructure development using alternative

Keywords： infrastructure development     contract design     contract reliability     guarantee provision     contract engineering    

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A naive optimization method for multi-line systems with alternative machines

Weichang KONG, Fei QIAO, Qidi WU

Frontiers of Mechanical Engineering 2019, Volume 14, Issue 4,   Pages 377-392 doi: 10.1007/s11465-019-0544-z

Abstract: Consequently, optimization of multi-line systems with alternative machines requires a simple mechanismTo define a general multi-line system with alternative machines, this study introduces the capability

Keywords： multi-line systems     alternative machines     feedback control     closed-loop optimization    

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High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Frontiers of Medicine   Pages 907-923 doi: 10.1007/s11684-023-1009-7

Abstract: The characteristic genetic abnormality of neuroendocrine neoplasms (NENs), a heterogeneous group of tumors found in various organs, remains to be identified. Here, based on the analysis of the splicing variants of an oncogene Focal Adhesion Kinase (FAK) in The Cancer Genome Atlas datasets that contain 9193 patients of 33 cancer subtypes, we found that Box 6/Box 7-containing FAK variants (FAK6/7) were observed in 7 (87.5%) of 8 pancreatic neuroendocrine carcinomas and 20 (11.76%) of 170 pancreatic ductal adenocarcinomas (PDACs). We tested FAK variants in 157 tumor samples collected from Chinese patients with pancreatic tumors, and found that FAK6/7 was positive in 34 (75.6%) of 45 pancreatic NENs, 19 (47.5%) of 40 pancreatic solid pseudopapillary neoplasms, and 2 (2.9%) of 69 PDACs. We further tested FAK splicing variants in breast neuroendocrine carcinoma (BrNECs), and found that FAK6/7 was positive in 14 (93.3%) of 15 BrNECs but 0 in 23 non-NEC breast cancers. We explored the underlying mechanisms and found that a splicing factor serine/arginine repetitive matrix protein 4 (SRRM4) was overexpressed in FAK6/7-positive pancreatic tumors and breast tumors, which promoted the formation of FAK6/7 in cells. These results suggested that FAK6/7 could be a biomarker of NENs and represent a potential therapeutic target for these orphan diseases.

Keywords： FAK6/7     SRRM4     neuroendocrine neoplasms     pancreas     breast    

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Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 1-7 doi: 10.1007/s11684-012-0173-y

Abstract: Individualized treatment in modern medicine is mainly established based on individual genome informationChinese constitutional theory developed in the 1970s expresses the principle behind Chinese health medicineIt promotes the study of the relationship of each constitution to diseases and Chinese medicine preparationdisease-differentiation, and syndrome-differentiation can be established for the development of individualized Chinese medicinetreatment and health medicine for the international medical community.

Keywords： individualized medicine     health medicine     constitutional theory in Chinese medicine    

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AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 2,   Pages 284-294 doi: 10.15302/J-FASE-2021435

Abstract:

Bioenergy, currently the largest renewable energy source in the EU (64% of the total renewable energy consumption), has sparked great interest to meet the 32% renewable resources for the 2030 bioeconomy goal. The design of innovative cropping systems informed by bioeconomy imperatives requires the evaluate of the effects of introducing crops for bioenergy into conventional crop rotations. This study aimed to assess the impacts of changes in conventional cropping systems in mixed dairy cattle farms redesigned to introduce bioenergy crops either by increasing the biomass production through an increase of cover crops, while keeping main feed/food crops, or by substituting food crops with an increase of the crop rotation length. The assessment is based on the comparison between conventional and innovative systems oriented to feed and biogas production, with and without tillage, to evaluate their agri-environmental performances (biomass production, nitrogen fertilization autonomy, greenhouse gas emissions and biogas production). The result showed higher values in the biogas cropping system than in the conventional and feed ones for all indicators, biomass productivity (27% and 20% higher, respectively), nitrogen fertilization autonomy (26% and 73% higher, respectively), methanogenic potential (77% and 41% higher, respectively) and greenhouse gas emissions (15% and 3% higher, respectively). There were no negative impacts of no-till compared to the tillage practice, for all tested variables. The biogas cropping system showed a better potential in terms of agri-environmental performance, although its greenhouse gas emissions were higher. Consequently, it would be appropriate to undertake a multicriteria assessment integrating agri-environmental, economic and social performances.

Keywords： alternative cropping systems / bioeconomy / biogas / biomass production / fertilization autonomy / greenhouse    

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Alternative energy development strategies for China towards 2030

Linwei MA , Zheng LI , Feng FU , Weidou NI , Xiliang ZHANG ,

Frontiers in Energy 2009, Volume 3, Issue 1,   Pages 2-10 doi: 10.1007/s11708-009-0014-0

Abstract: The purposes, objectives and technology pathways for alternative energy development are discussed withSpecial attention has been paid to alternative power and alternative vehicle fuels.Instead of limiting alternative energy to energy sources such as nuclear and renewable energy, the scopeof discussion is extended to alternative technologies such as coal power with carbon capture and sequestrationDesirable alternative fuels (or technologies) like 2nd generation biofuels and electrical vehicles should

Keywords： alternative energy     China energy     technology pathway     six-dimensional evaluation    

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Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 163-170 doi: 10.1007/s11684-011-0143-9

Abstract: in clinical practice, but without the benefit of undergoing the experimental medicine stage.medicine to Chinese medicine is appearing.The rapid transition and transformation from experience medicine to evidence-based medicine have becomeimportant content in the development of Chinese medicine., as well as transform and develop Chinese medicine from experience medicine to evidence-based medicine

Keywords： Chinese medicine     experience medicine     evidence-based medicine     real world    

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Experimental study of pollution effect on the behavior of high voltage insulators under alternative current

Hani BENGUESMIA, Nassima M’ZIOU, Ahmed BOUBAKEUR

Frontiers in Energy 2021, Volume 15, Issue 1,   Pages 213-221 doi: 10.1007/s11708-017-0479-1

Abstract: In this paper, the impact of the conductivity and the distribution of pollution on the behavior of the high voltage insulator cap and pin 1512L, artificially polluted is described. An experimental model in form of a disc is proposed. This experimental model reproduces the real model which is the 1512L insulator. Besides, a comparative study is presented. For this comparative study, different solutions are adopted to s`imulate the pollution (containing NaCl+ distilled water) that has different conductivities for a discontinuous distribution of the pollution on the insulator under an AC voltage. Furthermore, the influence of the pollution on the flashover voltage and the leakage current is studied. Finally, the behavior of real and experimental model of the insulator is investigated.

Keywords： 1512L insulator     circular model     artificial pollution     flashover     leakage current     discontinuous pollution     high voltage    

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Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Frontiers of Medicine 2014, Volume 8, Issue 3,   Pages 321-327 doi: 10.1007/s11684-014-0370-y

Abstract: preventive healthcare and symptom pattern differentiation for treatment in terms of traditional Chinese medicine

Keywords： big data     traditional Chinese medicine     clinical evaluation     evidence based medicine    

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Dimethyl ether as alternative fuel for CI engine and vehicle

Zhen HUANG , Xinqi QIAO , Wugao ZHANG , Junhua WU , Junjun ZHANG ,

Frontiers in Energy 2009, Volume 3, Issue 1,   Pages 99-108 doi: 10.1007/s11708-009-0013-1

Abstract: It is of great importance to develop clean and alternative fuels for internal combustion engines.

Keywords： dimethyl ether (DME)     fuel injection     combustion process     emission control     CI engine     vehicle    

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Research on Origin of Traditional Chinese Medicine

Fu Youfeng

Strategic Study of CAE 2006, Volume 8, Issue 9,   Pages 1-12

Abstract: , the author has explored the relationship between epidemic disease (especially bubonic plague) and medicineFrom the point of view that medicine comes of epidemic disease, the author has conducted research onrich resources of Chinese cultural relics, ancient writing and medical literature on medicine historyincluding the difference between ancient name and modem name of disease, difference between TCM and Western medicinepromotion of TCM achievement on epidemic disease and for the research on combination of TCM and Western medicine

Keywords： world medicine history     history of TCM     medicine origin     plague     cholera     smallpox     comparative medicine    

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Life cycle analysis and choice of natural gas-based automotive alternative fuels in Chongqing Municipality

WU Rui, LI Guangyi, ZHANG Zongyi, REN Yulong, HAN Weijian

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 3,   Pages 292-298 doi: 10.1007/s11783-007-0049-6

Abstract: A reduction of emissions can be achieved by implementing alternative fuel chains.

Keywords： dedicated     primary     economic     alternative     abundant    

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Title Author Date Type Operation

Molecular authentication of the traditional Chinese medicine Tongren Dahuoluo Wan and its alternative

Jikun WANG, Jing DU, Meng CAO, Lu YAO, Suhua XIE, Jiafu CHEN, Xingbo ZHAO

Journal Article

The unregulated commercialization of stem cell treatments: a global perspective

Douglas Sipp

Journal Article

Biofuel as an alternative to oil—current industry progress and sustainable development

Li Shizhong

Journal Article

Evaluation of the contract reliability for alternative infrastructure project delivery: a contract engineering

Bing WANG, Qingbin CUI, Shuibo ZHANG

Journal Article

A naive optimization method for multi-line systems with alternative machines

Weichang KONG, Fei QIAO, Qidi WU

Journal Article

High frequency of alternative splicing variants of the oncogene in neuroendocrine tumors of the pancreas

Journal Article

Individualized medicine, health medicine, and constitutional theory in Chinese medicine

Qi Wang

Journal Article

AGRI-ENVIRONMENTAL ASSESSMENT OF CONVENTIONAL AND ALTERNATIVE BIOENERGY CROPPING SYSTEMS PROMOTING BIOMASS

Journal Article

Alternative energy development strategies for China towards 2030

Linwei MA , Zheng LI , Feng FU , Weidou NI , Xiliang ZHANG ,

Journal Article

Thinking and practice of accelerating transformation of traditional Chinese medicine from experiencemedicine to evidence-based medicine

Baoyan Liu, Yanhong Zhang, Jingqing Hu, Liyun He, Xuezhong Zhou

Journal Article

Experimental study of pollution effect on the behavior of high voltage insulators under alternative current

Hani BENGUESMIA, Nassima M’ZIOU, Ahmed BOUBAKEUR

Journal Article

Clinical research of traditional Chinese medicine in big data era

Junhua Zhang,Boli Zhang

Journal Article

Dimethyl ether as alternative fuel for CI engine and vehicle

Zhen HUANG , Xinqi QIAO , Wugao ZHANG , Junhua WU , Junjun ZHANG ,

Journal Article

Research on Origin of Traditional Chinese Medicine

Fu Youfeng

Journal Article

Life cycle analysis and choice of natural gas-based automotive alternative fuels in Chongqing Municipality

WU Rui, LI Guangyi, ZHANG Zongyi, REN Yulong, HAN Weijian

Journal Article